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Senior/Principal Scientist, Proteomics

Company Overview

Founded in 2016, Foghorn Therapeutics discovers and develops novel drugs to treat cancer and other serious medical disorders. The company seeks to discover novel therapeutics that target chromatin remodeling complexes. Foghorn uses a proprietary platform based on revolutionary advances in mechanistic understanding of disease.

Job Summary

We are seeking a highly skilled and motivated mass spectrometry expert to become an integral member of the Foghorn team. This person will contribute to our goal of developing transformative therapeutics by planning, coordinating, and analyzing experiments related to the proteomic characterization of chromatin remodeling complexes. The main focus of this role will be proteomic analysis but will require a willingness to find new ways to think about scientific challenges. We need someone who is passionate, driven, and ambitious to help us achieve our goal of improving patients’ lives. 

Responsibilities and Duties


  • Collaborating with colleagues in biochemistry, biology, and chemistry to develop proteomics strategies.
  • Designing experiments to answer crucial questions about protein assemblies and protein-protein interactions.
  • Using established, or developing new, computational methods to analyze various proteomics data with the help of in-house software engineers.
  • Providing regular updates to cross-functional teams and helping guide protein complex optimizations.
  • Manage collaborations with contract research organizations (CROs) and academic partners.

Qualifications and Skills


  • PhD in Proteomics, Bioinformatics, Computer Science, or a related field with 4-6 years post-graduate experience (industry preferred). 
  • In-depth understanding of mass spectrometry laboratory techniques. 
  • Significant experience in analyzing and interpreting various types of proteomics data (e.g. post-translational modification analysis).
  • Expertise in mass spectrometry-based protein footprinting is highly preferred.
  • Excellent time management and communication skills. 
  • Ability to work in a fast-paced, team-driven environment, with a collaborative and proactive attitude.
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