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Associate Dir./Director, Computational Chemistry

TITLE:                  Principal Scientist/AD/Director, Computational Chemistry

REPORTS TO:    VP Chemistry

LOCATION:         Cambridge, MA



Founded in 2016, Foghorn Therapeutics discovers and develops novel drugs to treat cancer and other serious medical disorders. The company seeks to develop innovative therapeutics that target chromatin remodeling complexes. Foghorn leverages a proprietary platform based on revolutionary advances in the mechanistic understanding of genetically defined diseases.



The successful candidate will be responsible for independently leading computational chemistry at Foghorn Therapeutics. He/ she will be expected to drive and influence molecular design approaches by applying state of the art computational chemistry science. Of particular importance is the candidate’s ability to build strong working interactions with medicinal chemists and structural biologists. The successful candidate will be part of the chemistry leadership team.

Responsibilities include:

  • Work in close partnership with medicinal chemists as a united compound design team to improve potency, selectivity, and ADME properties while minimizing toxicological risk.
  • Set-up and develop computational chemistry infrastructure and software tools within Foghorn.
  • Develop deep understanding of project SAR, and in concert apply cutting edge computational chemistry methods to influence team strategy and compound design, and ultimately positively impact project direction
  • Maintain and develop working knowledge of contemporary computational chemistry methods and their use in ligand design and data analysis as applied to drug design projects.  


  • Ph.D. in a relevant scientific discipline with at least 9+ years of Computational Chemistry experience.
  • Sufficient experience and confidence to operate as sole internal computational chemistry resource and represent computational chemistry in a variety of cross-functional contexts.
  • Strong familiarity with a wide range of current computational chemistry software tools.
  • Expert molecular designer with creativity and the ability to design ligands & libraries; utilizes tools to evaluate/prioritize ideas.
  • Highly collaborative, team oriented professional with a passion for drug design. 
  • Experience with ligand and structure based computational chemistry activities.
  • A working knowledge of synthetic chemistry to enable independent compound design of synthetically tractable targets.
  • Model building and method development experience, informatics experience, and familiarity with high throughput screening, preferred but not required. 
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