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Scientist, Structural Biology


TITLE:                  Scientist, Structural Biology

REPORTS TO:     Senior Scientist, Drug Discovery

LOCATION:        Cambridge, MA


Founded in 2016, Foghorn Therapeutics discovers and develops novel drugs to treat cancer and other serious medical disorders. The company seeks to discover novel therapeutics that target chromatin remodeling complexes. Foghorn uses a proprietary platform based on revolutionary advances in mechanistic understanding of disease.


We are seeking a highly skilled and motivated structural biologist to become an integral member of the Foghorn team. This person will contribute to our goal of developing transformative therapeutics by planning and carrying out structural characterization of crucial drug targets. The main focus of this role will be protein crystallography but will require a willingness to find new ways to think about scientific challenges. We need someone who is passionate, driven, and ambitious to help us achieve our goal of improving patients’ lives.

Responsibilities include:

  • Collaborating with colleagues in biochemistry, biology, and chemistry to develop structural biology strategy.
  • Designing biophysics-grade protein constructs and assisting in the optimization of purification protocols.
  • Crystallization, X-ray structure determination, and analysis of important drug targets.
  • Providing regular updates to cross-functional teams and helping guide structure-based compound design in close collaboration with chemistry group.
  • Participating in the management of collaborations with contract research organizations (CROs) and academic partners.



  • PhD in Structural Biology, Biophysics, Biochemistry or a closely related field, with a background in chemistry.
  • Demonstrated competency in protein construct design and expression and purification strategies using bacterial, insect, and mammalian hosts. Experience with multi-protein complexes is a plus.
  • Deep expertise in protein crystallization and X-ray structure determination of protein-ligand complexes.
  • Extensive knowledge of protein structure and function, with the ability to articulately communicate structural information to a broad audience.
  • Experience with other structural techniques (e.g. electron microscopy, small-angle X-ray scattering) is preferred.
  • Excellent time management and communication skills.
  • Ability to work in a fast-paced, team-driven environment, with a collaborative and proactive attitude.
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