View Our Website View All Jobs

Sr./Principal Scientist, Chemistry

TITLE:                  Principal Scientist, Medicinal Chemistry

REPORTS TO:    VP Chemistry

LOCATION:        Cambridge, MA



Founded in 2016, Foghorn Therapeutics discovers and develops novel drugs to treat cancer and other serious medical disorders. The company seeks to develop innovative therapeutics that target chromatin remodeling complexes. Foghorn leverages a proprietary platform based on revolutionary advances in the mechanistic understanding of genetically defined diseases.


The successful candidate will be responsible for driving the design and synthesis of small-molecule drug candidates at all stages of drug discovery. As part of the medicinal chemistry team the successful candidate will analyze diverse data sets to build structure-activity relationships (SAR) that will then inform design hypotheses and medicinal chemistry strategy. In addition to the foregoing, the successful candidate will also be expected to take on a range of laboratory leadership and management activities, including project management of a laboratory move in early 2018.

Responsibilities include:

  • Design, plan and safely execute multi-step organic synthesis and purification of high quality target molecules.
  • Design high quality synthetic routes and help solve synthetic chemistry problems to open up chemical space for hypothesis testing.
  • Analyze complex data sets, develop deep SAR learning and proactively share within the group.
  • Develop medicinal chemistry strategies and create new design ideas through close collaboration with computational and medicinal chemists in the group.
  • Lead initial lab set-up and manage day to day running of the lab to ensure a smooth and safe operation
  • Stay up-to-date with literature in synthetic organic chemistry, advances in medicinal chemistry, and advances in broader modalities that influence oncology research.
  • Prioritize chemistry efforts to ensure timeline adherence and project alignment to meet company goals.
  • Assist in the preparation of patents, publications, and project planning.


  • Ph.D. in synthetic organic chemistry or other relevant discipline, with 5-8 years of industrial experience.
  • Significant experience of independent synthetic route design and problem solving towards complex molecules.
  • Skilled synthetic chemist who is able to work on both small and large scale, and deliver consistent high quality.
  • Experience working with external chemistry teams at CRO’s is preferred.
  • Ability to analyze complex data, distill learning and create new ideas.
  • Ability to champion chemistry efforts into new directions to achieve project milestones.
  • Strong evidence of conceptual thinking, active follow-through and vigorous scientific curiosity.
  • Proven ability to work well with others in a dynamic and highly collaborative environment.
  • Proactively shares expertise and ideas, demonstrates flexibility and open-mindedness.
  • Has a 'can do’ attitude, maintains consistent work level and motivation in the face of significant challenge.
Read More

Apply for this position

Apply with Indeed
Attach resume as .pdf, .doc, or .docx (limit 2MB) or Paste resume

Paste your resume here or Attach resume file