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Research Associate, Assay Development


TITLE:                  Research Associate, Drug Discovery

REPORTS TO:     Senior Scientist, Drug Discovery

LOCATION:        Cambridge, MA



Foghorn Therapeutics is a multidisciplinary team of scientists targeting chromatin remodeling to advance therapeutic approaches of drug discovery. We apply cutting-edge technology towards the discovery, characterization and optimization of small molecule therapeutics. 



We currently seek a highly motivated, creative and collaborative scientist to join our team in a hands-on role to discover the next generation of innovative approaches towards unmet medical needs.

Responsibilities include:

  • Functional and mechanistic characterization of enzymes, substrates, multi-protein complexes, and protein binding.
  • Design, development and troubleshooting of diverse biochemical and biophysical assays for use in the assessment of both mechanism and small molecule modulation of cancer targets, including hit identification, validation and optimization
  • Analysis, interpretation, documentation and presentation of data to local groups and project teams
  • Assessment of emerging technologies with an emphasis towards the adoption and implementation of new experimental techniques enabling drug discovery
  • Contribution to group knowledge and expertise through collaboration and idea exchange with multidisciplinary teams


  • BA/BS or MS degree in Biochemistry, Biophysics, Biology or a related field with 2-6 years of relevant industry experience.  
  • A solid understanding of protein function and enzyme mechanism; experience with biochemical and biophysical assay development for protein target and small molecule inhibitor characterizations as well as protein-ligand binding interactions
  • Experience with fluorescence-based assay techniques (e.g. HTRF, FP, quench assays) and label-free technologies (e.g. ITC, DSF, SPR, MST) is desired
  • Assay development experience which includes biochemical and whole cell assay formats is strongly preferred.  Examples would include ELISAs, MSD, and AlphaLISA/AlphaScreen
  • A basic understanding of compound management and ability to manage automated liquid handling instrumentation
  • Demonstrated ability to analyze, interpret and present data in a clear manner
  • An interest in contributing to medicinal chemistry drug discovery efforts to evaluate compound SAR and mode of action characterization
  • Excellent communication and inter-personal skills
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